Rejuvenation Therapy

Rejuvenation Therapy in Infertility

A decline in the quality and quantity of eggs over a period of years is a fact and no doubt in that, even though the aspiring mothers frequently forget it. A baby girl before her birth in her mother’s womb at around 5 months of pregnancy has the maximum number of 5 million eggs. At birth, the number comes down to 2 million and by the time she attains puberty the number dips down to 500,000. Each day hundreds of eggs are depleted and by the age of 40 years only a few hundreds will be left. Conditions such as endometriosis and infections make this process of depletion faster and surgeries done on the ovaries such as cystectomy or tubectomy can damage the ovaries considerably if not then meticulously.

Medications available in the market

Ovulogens such as Clomiphene Citrate and Gonadotropin injections act only on smaller eggs known as Antral Follicles. If there are no good number of Antral Follicles these injections and medicines are of no use and the patient will be advised to opt for Donor Eggs or Donor Embryo Transfers by the IVF Specialist. For those who want to use own eggs to have their own babies, there comes the help of Rejuvenation Therapy. Ovarian Rejuvenation is a therapy that may facilitate the growth of very tiny Pre-Antral Follicles which are lying dormant in the ovaries of women and normally not visible through the scan. These follicles do not respond to the Gonadotropins while undergoing the process of IVF-ICSI. Once these follicles come out of the stage from Pre Antral to Antral follicles, then the ovulogens act on them and she may ovulate. So here comes the benefit of rejuvenation therapy where around 60 ml blood is withdrawn from the patient and after undergoing special processing around 1.5 ml of serum rich in growth factors, platelets and other cells is obtained. This serum is injected into the ovaries through scan. We have been doing this over a couple of months. About 50 to 60% patients who either had a cancellation of previous IVF cycle or bad quality oocyte retrieval or had failed donor cycles have produced good number of follicles, eggs and embryos ultimately after this therapy.

But this does not ensure a 100% guarantee to get adequate number of own eggs to get a viable pregnancy in all the cases treated.

Rejuvenation therapy for repeat implantation failure

Persistant thin endometrium is another problem for patients as well as clinicians to achieve a healthy pregnancy. The uterine lining membrane known as the Endometrium has to reach a sufficient thickness of 8mm to 10mm to accept the embryos by the process of implantation and give sustinence and nourishment to the embryo to make it a full term viable foetus. This is possible only if the endometrium is thick and nourished well. In some cases, the uterine lining would be persistently thin and will be much resistant to any type of stimulation . These cases can also now be corrected by the process of Rejuvenation Therapy. In this process 50ml of blood is withdrawn from the patient is subjected to a process and at the end we get around 0.8ml serum which is rich in platelets and growth factors. This serum is injected into the uterine lining membrane that improves the implantation process.

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