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Rejuvenation Therapy in Infertility A decline in the quality and quantity of eggs over a period of years is a fact and no doubt in that, even though the aspiring mothers frequently forget it. A baby girl before her birth in her mother’s womb at around 5 months of pregnancy has the maximum number of 5 million eggs. At birth, the number comes down to 2 million and by the time she attains puberty the number dips down to 500,000. Each day hundreds of eggs are depleted and by the age of 40 years, only a few hundreds will be left. Conditions such as endometriosis and infections make this process of depletion faster and surgeries done on the ovaries such as cystectomy or tubectomy can damage the ovaries considerably, if not then meticulously.
Medications available on the market
Ovulogens such as Clomiphene Citrate and Gonadotropin injections act only on smaller eggs known as Antral follicles. If there are no good number of antral follicles, these injections and medicines are of no use and the patient will be advised to opt for Donor Eggs or Donor Embryo Transfers by the IVF Specialist. For those who want to use own eggs to have their own babies, there comes the help of Rejuvenation Therapy. Ovarian Rejuvenation is a therapy that may facilitate the growth of very tiny Pre-Antral follicles which are lying dormant in the ovaries of women and normally not visible through the scan. These follicles do not respond to the Gonadotropins while undergoing the process of IVF-ICSI. Once these follicles come out of the stage of Pre-Antral to Antral follicles, then the ovulogens act on them and the person may ovulate. So, here comes the benefit of rejuvenation therapy where around 60 ml blood is withdrawn from the patient and after undergoing special processing, around 1.5 ml of serum rich in growth factors, platelets, and other cells is obtained. This serum is injected into the ovaries through a scan.
We at CRAFT, have been doing this process over a couple of months. About 50 to 60% patients who either had a cancellation of previous IVF cycle or bad quality oocyte retrieval or had failed donor cycles have produced a good number of follicles, eggs, and embryos ultimately after this therapy.
But this does not ensure a 100% guarantee to get an adequate number of own eggs to get a viable pregnancy in all the cases treated.
Rejuvenation therapy for repeat implantation failure
Persistent thin endometrium is another problem for patients as well as clinicians to achieve a healthy pregnancy. The uterine lining membrane known as the Endometrium has to reach a sufficient thickness of 8mm to 10mm, for them to accept the embryos by the process of implantation and impart sustenance and nourishment to the embryo and thus, resulting in a full term viable fetus. This is possible only if the endometrium is thick and sufficiently nourished. In some cases, the uterine lining would be persistently thin and will be much resistant to any type of stimulation. These cases can also now be corrected by the process of Rejuvenation Therapy. In this process, 50ml of blood is withdrawn from the patient. It is then subjected to a process and at the end, we get around 0.8ml serum which is rich in platelets and growth factors. This serum is injected into the uterine lining membrane which helps in improving the implantation process.